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The purpose of this systematic review was to compare corticosteroid injections with non-steroidal anti-inflammatory drug (NSAID) injections for musculoskeletal painwith or without associated side effects in patients with arthritis. METHODS/DESIGN: We conducted a randomized placebo-controlled trial that included 25 patients with mild to moderate chronic back pain (mean: 54 yr, range: 26 to 96 yr), review altamofen. The patients were randomly assigned to receive 2 treatments and received the active drug (200 mg corticosteroid 3 times daily) on the third day, or the placebo on the fourth day, altamofen review. Informed consent was obtained from all patients enrolled in the study. RESULTS: The mean length of followup from random assignment was 48.5 months. The mean difference between the active and placebo groups was -4, anabolic steroid stack for mass.7 (95% confidence interval [CI]: -13, anabolic steroid stack for mass.8-0, anabolic steroid stack for mass.1), with a similar increase over time in the corticosteroid groups compared with the placebo groups (P<0, anabolic steroid stack for mass.01); the mean difference in the active drug groups was -4, anabolic steroid stack for mass.9 (95% CI: -15, anabolic steroid stack for mass.1-0, anabolic steroid stack for mass.6), with a similar decrease over time in the placebo groups compared with the corticosteroid groups (P < 0, anabolic steroid stack for mass.001); the difference in overall pain at 12 months was -4, anabolic steroid stack for mass.8 (95% CI: -17, anabolic steroid stack for mass.2 to -2, anabolic steroid stack for mass.9), with similar changes between groups over time (P = 0, anabolic steroid stack for mass.12); the difference in adverse events was -1, anabolic steroid stack for mass.9 (95% CI: -3, anabolic steroid stack for mass.4 to -0, anabolic steroid stack for mass.5) (P = 0, anabolic steroid stack for mass.06); the incidence of injection site hypersensitivity was similar (n = 15), anabolic steroid stack for mass. CONCLUSIONS: This trial confirms that corticosteroid injections are as effective in reducing pain and inflammation as NSAIDs for pain in patients with joint arthritis. While there are important differences between the 2 medicines, the efficacy of the corticosteroid injections is comparable to that of NSAIDs in this population.
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